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You Are On Multi Choice Question Bank SET 150
7501. During successful purification scheme, this may be expected that the
(A): both (a) and (c) (B): number of proteins in the sample decreases (C): specific activity decreases (D): specific activity increases
7502. In ion-exchange chromatography
(A): either (b) or (c) (B): proteins are separated on the basis of their net charge (C): proteins are separated on the basis of their shape (D): proteins are separated on the basis of their size
7503. Which of the following may be added to stabilize the protein after yeast cells disruption?
(A): All of these (B): AMP (C): NaCl (D): Protease inhibitor
7504. Gel-filtration chromatography separates on the basis of
(A): none of the above (B): shape using porous beads packed in a column (C): size and shape using porous beads packed in a column (D): size using porous beads packed in a column
7505. Affinity chromatography deals with the
(A): none of the above (B): protein - carbohydrate interaction (C): protein - protein interaction (D): specific binding of a protein constituents for another molecule
7506. Write the synonyms of the following words: Mild
(A): Gentle (B): Hard (C): Strong (D): Wild
7507. Had India played well, -------
(A): they could have won the world cup (B): they could not win the world cup (C): they could win the world cup (D): they could won the world cup
7508. Choose the correct one word :One who is specialised in cancer related diseases
(A): Gynaecologist (B): None of these (C): Oncologist (D): Surgeon
7509. " നവരത് നങ്ങൾ " ആരുടെ രാജസദസ്സിനെ അലങ്കരിച്ചിരുന്നു ? [" navarathu nangal " aarude raajasadasine alankaricchirunnu ?]
(A): അശോകൻ [Ashokan ] (B): വിക്രമാദിത്യൻ [Vikramaadithyan] (C): സമുദ്രഗുപ്തൻ [Samudragupthan ] (D): സ്കന്ദഗുപ്തൻ [Skandagupthan]
7510. I am looking forward to ............. from you
(A): have been heard (B): heard (C): hearing (D): hears
7511. Which of the following is the most correct?
(A): All hydrophobic amino acids are buried when a protein folds (B): Charged amino acids are never buried in the interior of a protein (C): Charged amino acids are seldom buried in the interior of a protein (D): Tyrosine is only found in the interior of proteins
7512. Which of the following forces is the most unfavorable for protein folding?
(A): Conformational entropy (B): Electrostatic interactions (C): Hydrophobic interactions (D): Vander Waals interactions
7513. Since ΔG° = -RTlnK
(A): a 10-fold decrease in K decreases ΔG° by about 2.3RT (B): a 10-fold decrease in K increases ΔG° by about 10-fold (C): a 10-fold increase in K decreases ΔG° by about 10-fold (D): a 10-fold increase in K decreases ΔG° by about 2.3RT
7514. The correlation between free energy ΔG transfer between the aqueous/organic phases and the surface area of amino acid residues
(A): ignores the important contribution of the peptide bond (B): is only meaningful for the polar amino acids (C): is similar to effects seen with SDS denaturation (D): reflects the reduction in solvent-accessible area during protein folding
7515. If the egg white protein, ovalbumin, is denatured in a hard-boiled egg, then which of the following is least affected?
(A): The primary structure of ovalbumin (B): The quaternary structure of ovalbumin (C): The secondary structure of ovalbumin (D): The tertiary structure of ovalbumin
7516. Buried hydrophobic side chains in a globular protein fit into a hole formed by the side chains of
(A): 1-3 other amino acids (B): 13-15 other amino acids (C): 5-7 other amino acids (D): 9-12 other amino acids
7517. Unpaired H-bond donors and acceptors are found in the hydrophobic core of a protein
(A): only at the ends of a-helices (B): only at the turns connecting p-strands (C): only on Pro residues (D): rarely
7518. For the unfolding reaction of Protein G, ΔH° =210.6 kJ/mol, this means that
(A): folding is favored enthalpically (B): the entropy is negative at all temperatures (C): the entropy is positive at all temperatures (D): unfolding is favored enthalpically
7519. Attractive Vander Waals forces occur between
(A): any pair of nearby atoms (B): apolar molecules in the liquid state (C): only if other forces are less favorable (D): polar molecules in the solid state
7520. Which of the following forces is the most favorable for protein folding?
(A): Conformational entropy (B): Hydrogen bonds (C): Hydrophobic Interactions (D): Vander Waals interactions
7521. At the midpoint of a temperature transition curve,
(A): All of these (B): half of the protein is denatured (C): Keq = 1.0 and ΔG = 0 (D): [Native] = [Unfolded]
7522. The synonym for ‘enmity’ is:
(A): Angularity (B): Eccentricity (C): Hostility (D): Oddity
7523. ‘To give up’ means
(A): to abandon (B): to break (C): to emit (D): to yield
7524. Opposite of the word ‘‘benal’’ is
(A): Arresting (B): Artificial (C): Heady (D): Temporary
7525. Could you............. me your pen?
(A): have lent (B): lend (C): lending (D): lent
7526. താഴെപ്പറയുന്നതില് ഫിറോസ്ഷാ തുഗ്ലക്കിനാല് സ്ഥാപിക്കപ്പെടാത്ത പട്ടണമേത് ? [Thaazhepparayunnathilu phirosshaa thuglakkinaalu sthaapikkappedaattha pattanamethu ?]
(A): ജാന് പൂര് [Jaanu pooru ] (B): തുഗ്ലക്കാബാദ് [Thuglakkaabaadu ] (C): ഫിറോസ്ഷാബാദ് [Phirosshaabaadu] (D): ഹിസാര് [Hisaaru ]
7527. Marfan's syndrome is thought to be a mutation affecting
(A): collagen synthesis (B): hemoglobin synthesis (C): insufficient thyroid production (D): metabolism of homogentisic acid
7528. Cyclins are proteins that
(A): none of the above (B): regulate ability of cells to invade tissue (C): regulate apoptosis of damaged cells (D): regulate passage from one stage of cell division to another
7529. Over 50% of common cancers are associated with damage to a protein, p53. This protein
(A): is a cyclin (B): is a tumor supressor (C): is an oncogene (D): regulates apoptosis
7530. Protein folding is
(A): automatic, mediated by the protein itself (B): mediated by other proteins called chaperones (C): mediated by the ribosomes (D): none of the above
7531. Sickle cell disease is due to
(A): a mutation in the alpha chain of Hb (B): a mutation in the beta chain of Hb (C): infection with a parasite (D): none of the above
7532. The four subunits of the hemoglobin (Hb) gene represent protein's
(A): primary structure (B): quaternary structure (C): secondary structure (D): tertiary structure
7533. Beta pleated sheets are examples of protein's
(A): primary structure (B): quaternary structure (C): secondary structure (D): tertiary structure
7534. BRACl, an inherited form of breast cancer, regulates cell division by
(A): binding to a DNA sequence (B): binding to the cell outer membrane (C): binding to the protein RAD 51 which repairs DNA damage (D): complexing with cyclins
7535. Metastasis involves
(A): ability of cells to dissolve cellular matrix (B): all of the above (C): decreased levels of proteins that regulate metalloproteins (D): metalloprotein levels
7536. Signal sequences are part of a protein that
(A): refold proteins in prion-associated diseases (B): signal folding of the protein (C): signal the protein synthesis on the ribosomes is ended (D): transport proteins to other sites within the cell
7537. Individuals with PKU disease are mentally retarded unless
(A): homogentisic acid in the diet is restricted (B): none of the above (C): phenylalanine in the diet is restricted (D): tyrosine in the diet is restricted
7538. He ........ very quickly when I met him yesterday
(A): has been walking (B): has walked (C): walks (D): was walking
7539. It is such _______useful article.
(A): a (B): an (C): no article (D): the
7540. ‘Pseudonym’ means
(A): false name (B): nick name (C): none of these (D): surname
7541. The antonym of acquit is:
(A): condemn (B): defeat (C): indigenous (D): relax
7542. The temple is at the top of the hill and the ............is very sleep
(A): accent (B): access (C): ascent (D): assent
7543. Amino acids are joined together into a protein chain by which of the following?
(A): DNA polymerase (B): Hydrogen bonds (C): Messenger RNA (D): Transfer RNA
7544. Phosphorus is taken up by the cell during the process of
(A): ATP synthesis. (B): carbohydrate synthesis. (C): lipid synthesis. (D): protein synthesis,
7545. Protein synthesis rates in prokaryotes are limited by the rate of mRNA synthesis. If RNA synthesis occurs at the rate of 50 nucleotides/sec, then rate of protein synthesis occurs at
(A): 10 amino acids/sec (B): 17 amino acids/sec (C): 25 amino acids/sec (D): 50 amino acids/sec
7546. The site of protein synthesis is
(A): Chromosome (B): Endoplasmic reticulum (C): Nucleus (D): Ribosome
7547. The structure in a bacterium that indicates an active site for protein synthesis is
(A): a cell membrane, (B): a chromosome. (C): a flagellum. (D): a polysome.
7548. The lac operon contains the z, y and a structural genes
(A): encoding p-galactosidase and galactose permeases (B): encoding P-galactosidase only (C): encoding p-galactosidase, galactose permeases and thio-galactosidase transacetylase respectively (D): None of the above
7549. Proteins contain __________ different amino acids, whereas DNA and RNA are composed of __________ different nucleotides
(A): 20,4 (B): 20,64 (C): 3,20 (D): 4,20
7550. Which of the following is not necessary for protein synthesis to occur, once transcription is completed?
(A): DNA (B): mRNA (C): Ribosomes (D): tRNA
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