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1. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
(A): activation of B cells by T-independent antigens
(B): failure of B cells to provide co-stimulation for Th2 activation
(C): failure of Th2 cells to provide co-stimulation for B cell isotype switching
(D): failure of Th2 cells to provide co-stimulation for B cell proliferation
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